Monte Rosa Therapeutics is seeking a Research Associate/Senior Research Associate - Biology to support early target validation in immunology and inflammation, aiding in the advancement of our molecular glue degraders into clinic. The successful candidate will collaborate with team members to design and execute in vitro experiments focused on determining the activity and mechanism of action of compounds. This role requires hands-on laboratory work, conducting a variety of in vitro experiments.

Monte Rosa Therapeutics (MRT) is a clinical-stage biotechnology company pioneering the discovery and development of molecular glue degraders (MGDs) to eliminate disease-causing proteins previously considered undruggable. We are seeking an accomplished and collaborative Senior Director of Medicinal Chemistry to lead and shape our drug discovery efforts in Boston. This leadership role will be central to advancing our growing pipeline from hit identification through development candidate nomination and IND-enabling studies. The ideal candidate will bring deep medicinal chemistry expertise, strong leadership capabilities, and a passion for driving innovative science toward transformative medicines.

Monte Rosa Therapeutics is searching for a Sr Research Associate - In Vivo to assist in executing pivotal proof-of-concept studies in pre-clinical models in mice of inflammation, immunology, and oncology, and assist in the cross-functional development of our research strategy. The role involves interacting with team members to design and execute in vivo/ex vivo pharmacology studies aimed at defining the activity and mechanism of action of compounds. This person will work primarily in our Animal Care Facility, ideally 10am-6pm, to oversee and perform afternoon/evening and weekend dosing of animals as part of study...

Monte Rosa Therapeutics is seeking a Director Quality GCP to provide strategic oversight of phase-appropriate  Quality GCP and GCLP activities, including GCP quality oversight of ongoing quality activities supporting active pre-clinical and clinical programs through participation on in-house and external cross-functional teams.  This role requires an 75% on-site presence. You will work closely with industry leaders in Boston and Basel . Join a diverse, collaborative, and dynamic team that values innovation, teamwork, and a people-centric culture!

Monte Rosa Therapeutics is seeking an Intern in Bioinformatics Data Sciences to contribute to the elimination of disease-causing proteins through targeted protein degradation—a groundbreaking approach designed to address proteins previously considered undruggable. Successful candidates will gain direct experience within an early-stage drug discovery environment and have the opportunity to focus on areas that align with their interests. You will work closely with industry leaders who will mentor you throughout your project, expose you to additional drug discovery initiatives, and guide you in solving complex biological challenges. Join a diverse,...

Monte Rosa Therapeutics is seeking passionate Internship Research Associate to help us to eliminate disease causing proteins through targeted protein degradation­­–a novel and exciting way of drugging proteins that until recently were considered un-druggable­. The candidates will gain hands-on experience within a particular area of interest in an early-stage drug discovery environment. You will work with an industry leader who will direct and mentor you on your project, expose you to other drug discovery projects and involve you in solving complex biological questions. You will be joining a...

Monte Rosa Therapeutics is seeking a passionate candidate for an internship in the Immunology and Inflammation Biology group to help us identify molecular glue degraders to eliminate disease causing proteins through targeted protein degradation ­­­– a novel and exciting field for targeting proteins that were previously considered un-druggable. The candidate will contribute to enhancing protein degradation in primary human immune cells to guide discovery and prioritization of novel targets. This internship will...

The Biosample Operations Manager will be accountable for the clinical and non-clinical sample planning, processing, tracking, reconciliation, and life-cycle management to maintain chain-of- custody in a GxP-compliant setting.

Monte Rosa Therapeutics is seeking an experienced and strategic Director of Regulatory Affairs to lead and support global regulatory efforts across our development programs, with a focus on immunology. The ideal candidate will be responsible for developing and executing regulatory strategies that support global product development and registration. This role requires strong regulatory knowledge, leadership skills, and the ability to work effectively in a cross-functional environment. Global regulatory experience is required, and immunology background is preferred. CMC experience is a plus.

Monte Rosa Therapeutics seeks to recruit a highly motivated research associate to join its proteomics group in Boston. This is an exciting opportunity to join a team responsible for target identification of novel small molecule degraders. The successful candidate will be responsible for independently conducting his/her own experiments from sample preparation, LC-MS acquisition, to data analysis, interpretation, and presentation of the proteomics results. The candidate should exhibit excellent communication and collaborative skills for working on cross-functional multi-disciplinary drug discovery teams.

Monte Rosa Therapeutics is seeking passionate a Co-op Research Associate to help us design assays for targeted protein degradation – a novel drug mechanism that has expanded the scope of disease treatments. The intern will gain in-depth knowledge and hands-on experience in biochemical assay development of TR-FRET and AlphaLISA assays, in addition to skills in automation systems and high throughput screening. You will work with an industry leader who will direct and mentor you on your project, as well as expose you to other drug discovery projects and involve you in the process of solving complex biological questions. You will be joining a diverse, thoughtful, fun and collaborative environment that emphasizes teamwork and putting...

Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager will assit in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research, Bioanalytical and Clinical Science subject matter experts, provides scientific expertise to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized. Represents Preclinical Development on Research and Development teams and...

Monte Rosa Therapeutics is seeking a highly skilled and motivated Compound Manager to consolidate and maintain a Compound management function in Boston, in close collaboration with our Basel Compound management team. The successful candidate will be accountable for storage, retrieval and distribution of Monte Rosa’s compound collection for biological profiling, both internally and externally across global sites. Working closely with Chemistry, Biology, Screening, Data Science, and Facilities groups, the candidate should exhibit excellent communication and collaborative skills for working on cross-functional teams, as well as demonstrate a high degree of independence and organization.

We are seeking an energetic and highly motivated individual to join our Clinical Operations team.  This position reports to the Head of Clinical Operations and is an opportunity to significantly contribute to the growth and development of a top-tier Biotech company. The CTA position is focused on providing support associated with the planning, start-up, maintenance, and closeout of clinical trials. The ideal candidate will be proactive and detail oriented with a desire to be involved in all aspects of clinical trial execution.

Monte Rosa Therapeutics is seeking a contractor (initial 6 months) with the experience to implement and run complex cellular assays. This position is a key role in the pivotal team responsible for Automation and Screening Technologies & hits-to-leads support for Monte Rosa’s diverse pipeline. The ideal candidate will be able to help evolve Monte Rosa’s hit identification and hits-to-leads endeavors through embracing novel assay technologies, enhancing overall processes and actively drive internal and external partnerships.

We are looking for a highly motivated and detail-oriented staff accountant to join our accounting team. In this high impact role, you will perform day-to-day financial operations and compliance functions. You will be responsible for month-end close processes, and partner with the finance and cross-functional teams to drive continuous improvement in financial operations. This is an opportunity for a resourceful candidate to develop and implement systems, processes, and internal controls to support a high-growth innovative organization.

Monte Rosa Therapeutics is seeking an experienced and strategic Director of Clinical Data Management to lead and grow our data management function. This role is ideal for a hands-on leader who thrives in a fast-paced biotech environment and is passionate about building scalable data systems that support high-quality clinical trials. You will be responsible for overseeing all aspects of clinical data management across our pipeline, ensuring data integrity, compliance, and readiness for regulatory submission.

Monte Rosa Therapeutics is looking for an experienced Office Administrator to join our global high energy office operations team. This individual will be responsible for Basel office operations as well as providing administrative support for 2 executives located in the Basel office. This individual will manage multiple administrative tasks and will be expected to work with a high degree of autonomy.   The ideal candidate will have at least 3-5 years of administrative experience, proven organizational, administrative and interpersonal skills, as well as experience working with senior executives. Experience within the biotech or pharma industry is preferred but is not a requirement.

Monte Rosa Therapeutics (MRT) seeks to recruit an enthusiastic, creative and highly talented scientist to join our growing CMC group in Basel supporting the discovery of molecular glue degraders (MGDs) that eliminate disease-causing proteins previously thought undruggable. In this exciting role the successful candidate will contribute to all CMC tasks from discovery/preclinical stage to clinical and potentially commercial stage. This includes managing outsourcing activities for development and manufacturing of both drug substance and drug product and early...

Monte Rosa Therapeutics is seeking a European Patent Attorney to manage its patent portfolio, protect innovations, and contribute to global intellectual property strategy, particularly in relation to small molecule chemistry. The role involves drafting and prosecuting chemical and pharmaceutical patent applications globally, providing IP legal support across departments, and collaborating with external counsel and partners. Candidates should have an advanced degree in chemistry, admission to practice as a European Patent Attorney, at least five years of pharmaceutical patent law experience, and expertise in the drafting and prosecution of small molecule patent applications.

Monte Rosa Therapeutics. looking for a Director Quality GMP with quality expertise to support all GMP/GDP quality aspects of externally produced supply of drug substance and drug product for novel molecular glue degrader (MGD) programs, making a difference for our patients every day. Responsible for oversight of phase-appropriate Monte Rosa Quality GMP and GDP activities. These activities include; cGMP quality oversight of ongoing manufacturing, testing and distribution activities supporting active pre-clinical and clinical programs through participation on in-house and external cross-functional teams. The right candidate...