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Monte Rosa Therapeutics is seeking a highly motivated scientist to help advance our existing DNA-Encoded Library (DEL) platform. We are looking for an individual with deep expertise in DEL library design, encoding strategies, selection technologies, and hit triaging, who is passionate about developing innovative approaches that expand our DEL capabilities and accelerate drug discovery. Working with internal and external partners at the interface of Chemistry, Biology, Data Science, and Biophysics the successful candidate will contribute to the design of next-generation libraries, optimization of selection methodologies, and development of novel DEL technologies that enable the discovery of high-quality chemical starting points for challenging targets. This contract...
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Monte Rosa Therapeutics is seeking a highly skilled and self-motivated regulatory professional to join our team as an Associate Director of CMC Regulatory Affairs. The CMC Regulatory Affairs will serve as a key regulatory strategist and author for the Chemistry, Manufacturing, and Controls components of Monte Rosa's global regulatory filings. This individual will partner closely with Process Chemistry, Analytical Development, Drug Product, Quality, and Clinical Supply teams to develop CMC regulatory strategy, author and review high-quality submission content (Module 3 and associated summaries), and represent CMC in interactions with health authorities. The role requires strong technical CMC knowledge, regulatory acumen...
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Monte Rosa Therapeutics is seeking a Clinical Systems Specialist to join our IT team as the technical bridge between Clinical Operations, Clinical Data Science, and Biomarkers, and the systems that run underneath them. This hands-on, builder-oriented role owns support of our clinical operations systems (EDC, IRT/RTSM, eTMF) and, just as importantly, builds the data pipelines and integrations that move information reliably between those systems and our internal data platform — so Clinical Data Scientists and the Biomarkers team spend their time on analysis, not wrangling data. Automation and reducing toil are core to the role, and you’ll work closely with the rest of the IT team on thoughtful application of our technology stack to support the...
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Monte Rosa Therapeutics is seeking a Senior Research Associate I/II to support the design and execution of in vivo proof-of-concept studies across oncology, inflammatory disease, and autoimmune disease programs. Working closely with cross-functional teams, this individual will execute in vivo pharmacology studies designed to characterize the activity and mechanism of action of novel compounds. The successful candidate will work in our AAALAC-accredited Animal Care Facility and provide occasional evening and weekend study support, including animal dosing, as required by study protocols. The position level will be determined based on the candidate’s qualifications and experience....
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Monte Rosa Therapeutics is seeking an energetic and highly motivated B-Cell Biologist for a 6 month contract, located in Boston to support the development and characterization of novel molecular glue degraders for the treatment of autoimmune and inflammatory diseases. As part of the Discovery Immunology team, this role will broadly support multiple immunology and inflammation (I&I) projects/programs, both in vitro and ex vivo, from early discovery through lead optimization.
The ideal candidate is an immunologist with a strong technical background in B cell immunology, particularly with primary human and mouse cells/tissues, and a demonstrated ability to move projects/programs forward through collaborative...
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We are seeking a hands-on, versatile Technology Specialist — a true "jack of all trades" combining end-user computing, systems administration, and network support with a forward-looking mandate: helping our scientists and G&A teams work smarter through automation, AI-enabled tooling, and thoughtful use of our technology stack. The ideal candidate is a proactive problem-solver who takes initiative, moves fluidly between a support ticket, a patch cycle, and a workflow-automation experiment in the same day, and is genuinely excited about the potential of AI and agentic tools to reduce toil across the organization.
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We are seeking an energetic and highly motivated individual to join our Clinical Operations team. This position reports to the Head of Clinical Operations and is an opportunity to significantly contribute to the growth and development of a top-tier Biotech company. The COA position is focused on providing support associated with the planning, start-up, maintenance, and closeout of clinical trials. The ideal candidate will be proactive and detail oriented with a desire to be involved in all aspects of clinical trial execution.
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MRTx is seeking a highly experienced Clinical Trials Manager with experience in Ocology or I & I to lead the successful planning, implementation, and conduct of clinical trials across multiple oncology/non-oncology indications. Reporting to the Head of Clinical Operations, the Sr. Clinical Trial Manager, Clinical Operations will be responsible and accountable for development of operational program strategy and leading execution of First in Human through Phase III trials depending on program life cycle, representing clinical operations on cross functional Program Teams, and managing clinical operations team members to ensure adherence with overall study timelines, budget, quality ,and regulatory standards (ICH/GCP ,internal SOPs). This role will be...
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Monte Rosa Therapeutics is seeking a highly experienced Clinical Operations professional to lead the successful planning, implementation, and conduct of clinical trials across multiple indications. Reporting to the Head of Clinical Operations, the Associate Director, Clinical Operations will be responsible and accountable for development of operational program strategy and leading execution of First in Human through Phase III trials depending on program lifecycle, representing clinical operations on cross functional Core Teams, and managing clinical operations team members to ensure adherence with overall study timelines, budget, quality, and regulatory standards (ICH/GCP, internal SOPs). A genuine interest and understanding of the science...
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The Clinical Research Associate (CRA) supports clinical trial quality, compliance, and execution through site monitoring, study startup, data oversight, and regulatory documentation. The CRA will also serve as an in-house sponsor representative overseeing CROs and third-party monitoring vendors, ensuring delegated activities meet protocol, GCP, quality, and timeline requirements. This role will be supporting Phase I-III clinical trials , the ideal candidate will have experience in Oncology indications or I &I. The CRA will have the ability to work Hybrid work arrangement with Boston office MRTx requires a 70% office presence. .Availability for approximately 30–40% travel is...
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At Monte Rosa Therapeutics, we’re excited to seek a dedicated Compound Manager to join our team. You’ll play a pivotal role within our Compound Management Team, working closely with colleagues to deliver compounds in a variety of formats for the Screening Teams. Your expertise will directly support the characterization of innovative small molecule glue-based degraders and drive the advancement of our expanding pipeline. If you’re passionate about collaboration, innovation, and making a real impact in scientific discovery, we’d love to meet you.
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We are seeking a hands-on, versatile Technology Specialist — a true "jack of all trades" combining end-user computing, systems administration, and network support with a forward-looking mandate: helping our scientists and G&A teams work smarter through automation, AI-enabled tooling, and thoughtful use of our technology stack. The ideal candidate is a proactive problem-solver who takes initiative, moves fluidly between a support ticket, a patch cycle, and a workflow-automation experiment in the same day, and is genuinely excited about the potential of AI and agentic tools to reduce toil across the organization.
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Monte Rosa Therapeutics is seeking a Senior Director Quality GCP to provide strategic oversight of phase-appropriate Quality GCP and GCLP activities, including GCP quality oversight of ongoing quality activities supporting active pre-clinical and clinical programs through participation on in-house and external cross-functional teams. This role requires an 75% on-site presence. You will work closely with industry leaders in Boston and Basel . Join a diverse, collaborative, and dynamic team that values innovation, teamwork, and a people-centric culture!
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Monte Rosa is looking for an experienced Program and Alliance Manager with research and early clinical development experience in biotech to oversee internal and partnered programs. Leveraging their drug development, project management and cross-functional team experience, the successful candidate will manage early-stage internal programs in close collaboration with program leaders, to successfully advance our pipeline. The candidate will be responsible for managing program-related activities, resolving issues, tracking progress of key milestones and budget, and achieving project goals. In addition, this individual will develop and maintain key relationships, both internally and externally, to ensure effective...
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Monte Rosa Therapeutics seeks an experienced, highly organized, and collaborative People Experience Operations (HR) Generalist to support and enhance our people operations function. This role will be responsible for managing core HR processes, systems, compliance activities, and employee lifecycle programs while helping to scale a high-performing and employee-focused global organization.
The ideal candidate thrives in a fast-paced, innovative environment and brings a continuous improvement mindset, strong analytical capabilities, and exceptional attention to detail.
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The Manager, Data Management will be responsible for overseeing clinical data management activities across one or more clinical programs. This individual will work closely with Clinical Operations, Biostats and Programming, Medical, Safety, Regulatory, external CROs, and technology vendors to ensure high-quality, inspection-ready clinical data.
This is a hands-on role well suited for someone who thrives in a small biotech environment, can...
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The Associate Director of Program Management will serve as a strategic and operational leader for priority immunology and inflammation programs, driving assets from mid- to late-stage development through regulatory submission. This role is designed for a hands-on, agile leader who thrives in a fast-paced biotechnology environment and can rapidly translate evolving science into executable development strategy.
As a core member of the Program Team, the Director will partner closely with Clinical, Regulatory, CMC, Nonclinical, Biomarkers, Translational Sciences, and Commercial leaders to integrate strategy and execution across the full development lifecycle. This individual will ensure alignment to the Target Product Profile (TPP) and...
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Responsible for the coordination and preparation of document packages for regulatory submissions ensuring compliance with the Food and Drug Administration (FDA) and international regulations/interpretations. May determine methods and procedures on some assignments and may provide guidance to other lower-level personnel.
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The Director of Drug Safety & Pharmacovigilance provides strategic and hands‑on leadership for pharmacovigilance activities supporting a clinical‑stage biotech pipeline in inflammatory and oncology diseases. This role is responsible for establishing and executing global safety strategy across early‑ and mid‑stage clinical programs, with particular focus on immune‑mediated toxicities, oncology risk management, and complex benefit–risk assessment. The Director partners closely with Clinical Development and Regulatory teams to integrate safety...
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The Director of Biostatistics is a hands‑on statistical leader responsible for the design, analysis, and interpretation of Phase 1–Phase 3 clinical trials with a primary focus on inflammation and oncology indications. This role combines scientific leadership with active execution and intensive CRO oversight, ensuring high‑quality statistical deliverables across outsourced clinical studies.
The Director will work closely with Clinical Development and external partners to drive trial design, analysis strategies, and...
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Monte Rosa Therapeutics is seeking an experienced and strategic Director of Regulatory Affairs to lead and support global regulatory efforts across our development programs, with a focus on immunology. The ideal candidate will be responsible for developing and executing regulatory strategies that support global product development and registration. This role requires strong regulatory knowledge, leadership skills, and the ability to work effectively in a cross-functional environment. Global regulatory experience is required, and immunology background is preferred. CMC experience is a plus.