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Monte Rosa Therapeutics is seeking a passionate Senior Research Associate with the experience to implement and run biochemical and biophysical characterization assays. This is an exciting opportunity to join a team responsible for the characterization of novel small molecule glue-based degraders to support Monte Rosa’s growing pipeline. The successful candidate will have proven bench level expertise in establishing and performing a range of biochemical and biophysical assays to screen and characterize small molecule compounds and elucidate mechanism of action.
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Monte Rosa Therapeutics seeks an experienced, highly organized, and collaborative People Experience Operations (HR) Generalist to support and enhance our people operations function. This role will be responsible for managing core HR processes, systems, compliance activities, and employee lifecycle programs while helping to scale a high-performing and employee-focused global organization.
The ideal candidate thrives in a fast-paced, innovative environment and brings a continuous improvement mindset, strong analytical capabilities, and exceptional attention to detail.
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Monte Rosa Therapeutics is seeking an energetic and highly motivated Contractor located in Boston to support the development and characterization of novel molecular glue degraders for the treatment of inflammatory diseases. As part of the Immunology and Preclinical Pharmacology team, this role will broadly support multiple immunology and inflammation (I&I) projects/programs from early lead optimization through clinical-stage.
The ideal candidate is an experienced experimentalist with a strong background in I&I and a demonstrated ability to work collaboratively to achieve team/company goals.
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The Manager, Data Management will be responsible for overseeing clinical data management activities across one or more clinical programs. This individual will work closely with Clinical Operations, Biostats and Programming, Medical, Safety, Regulatory, external CROs, and technology vendors to ensure high-quality, inspection-ready clinical data.
This is a hands-on role well suited for someone who thrives in a small biotech environment, can...
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The Manager, GMP Quality is responsible for the oversight and day-to-day quality interface with CDMO producing DS & DP for MRTx's ongoing clinical programs.. This includes supporting the review of MBRs/EBRs, analytical methods, validation protocols/reports, specifications, release data packages and stability protocols/report. This role will also supportextneral audits , inspection readiness and regulatory authority inspections.
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Monte Rosa Therapeutics seeks an experienced and highly motivated scientist to join our Biomarker and Translation team in Boston. Using a rational approach to targeted protein degradation, Monte Rosa is developing pioneering therapies across Immunology & Inflammation, Oncology, and other disease areas. The individual in this role will be responsible for designing and executing robust translational experiments in clinically relevant models to support indication selection and patient stratification. He/she will work in close collaboration with translational/biomarker, project and clinical teams to develop and implement internal and external biomarker activities and perform studies...
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The Manager, Document Management and Training is responsible for the oversight of the Document Management and Training Management systems and processes. This includes supporting Quality Metric reporting at QMS Boards and Management Review meetings. This role will also support internal audits (related to document and training management), inspection readiness and regulatory authority inspections. In addition, this role will continuously improve GXP Document and Training processes and lead changes in the organization.
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Monte Rosa Therapeutics is searching for a Toxicology Lead to direct nonclinical safety and toxicology work for programs to enable drug candidates from discovery through development. This position will lead and develop nonclinical toxicology strategies to support Monte Rosa’s diverse drug candidates during all phases of development. The Toxicology Lead will contribute to the R&D strategy and implement the strategy and will report to the Senior Director of Nonclinical Development. This is an individual contributor role by designing, conducting or overseeing studies, analyze/interpret, and report in vitro, ex vivo, and in vivo non-GLP (or GLP...
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Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager will assit in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research,...
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We are seeking an experienced and strategically minded Associate Director, Corporate Communications to lead the execution of our external communications strategy.
The Associate Director, Corporate Communications will oversee corporate communication across press releases, investor materials, company website, social media, and components of SEC filings such as the annual report (Form 10‑K). The ideal candidate combines strong communications expertise with scientific literacy and a solid understanding of the biopharmaceutical sector, allowing this person to translate complex scientific and clinical data into clear and engaging narratives for investors, media, and other key...
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Monte Rosa Therapeutics, an industry leader in targeted protein degradation (TPD), is seeking a passionate intern in Cell Biology to help us eliminate disease-causing proteins that were previously considered undruggable through our novel and exciting TPD platform. You will work closely with experienced scientists who will direct and mentor you on your project, while also exposing you to other drug discovery projects and involving you in solving complex biological questions. You will be joining a diverse, thoughtful, fun and collaborative environment that emphasizes teamwork and putting people first! This role is slated for a September 2026 or sonner start.
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To support our growing pipeline, we are looking to fill an exciting position at Monte Rosa Therapeutics. The CMC team is looking for a Scientist, Analytical CMC& QC with Analytical expertise to support analytical activities related to the development and supply of drug substance and drug product for molecular glue degrader (MGD) programs. The successful candidate will be involved in Chemistry, Manufacturing and Control activities from preclinical to clinical and potentially commercial stage. This includes but is not limited to managing, monitoring and guiding analytical activities, such as methods development, phase appropriate validations, stability studies, release...
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In this exciting role the successful candidate will contribute to CMC tasks from discovery/preclinical stage to clinical and potentially commercial stage. This includes managing outsourcing activities for development and manufacturing of drug substance from early phase onwards, including route scouting, process development and compounds supply from pre-IND to clinics. The role might imply involvement in drug product development activities from and early formulation to development and manufacturing. Strong experience in process chemistry of small molecule APIs, the desire to work in a fast-paced dynamic environment, excellent team working and cross-functional collaboration are...
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Responsible for support of phase-appropriate Monte Rosa Quality GCP and GCLP activities, including GCP quality oversight of ongoing quality activities supporting active pre-clinical and clinical programs through participation on in-house and external cross-functional teams.
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The Associate Director of Program Management will serve as a strategic and operational leader for priority immunology and inflammation programs, driving assets from mid- to late-stage development through regulatory submission. This role is designed for a hands-on, agile leader who thrives in a fast-paced biotechnology environment and can rapidly translate evolving science into executable development strategy.
As a core member of the Program Team, the Director will partner closely with Clinical, Regulatory, CMC, Nonclinical, Biomarkers, Translational Sciences, and Commercial leaders to integrate strategy and execution across the full development lifecycle. This individual will ensure alignment to the Target Product Profile (TPP) and...
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Responsible for the coordination and preparation of document packages for regulatory submissions ensuring compliance with the Food and Drug Administration (FDA) and international regulations/interpretations. May determine methods and procedures on some assignments and may provide guidance to other lower-level personnel.
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Monte Rosa Therapeutics is searching for a Toxicology Lead to direct nonclinical safety and toxicology work for programs to enable drug candidates from discovery through development. This position will lead and develop nonclinical toxicology strategies to support Monte Rosa’s diverse drug candidates during all phases of development. The Toxicology Lead will contribute to the R&D strategy and implement the strategy and will report to the Senior Director of Nonclinical Development. This is an individual contributor role by designing, conducting or overseeing studies, analyze/interpret, and report in vitro, ex vivo, and in vivo non-GLP (or GLP...
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The Director Clinical Scientist is an important and visible member of the Clinical Development team, working collaboratively with the Clinical operations lead and medical director. The Director Clinical Scientist will be responsible for scientific oversight, data integrity and quality of clinical trial(s) in support of the development strategy for programs within the Early- stage portfolio. The role is the primary contact for internal and external stakeholders for clinical aspects of the protocol, supporting strategic development, providing final recommendations to senior management.
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The Director of Drug Safety & Pharmacovigilance provides strategic and hands‑on leadership for pharmacovigilance activities supporting a clinical‑stage biotech pipeline in inflammatory and oncology diseases. This role is responsible for establishing and executing global safety strategy across early‑ and mid‑stage clinical programs, with particular focus on immune‑mediated toxicities, oncology risk management, and complex benefit–risk assessment. The Director partners closely with Clinical Development and Regulatory teams to integrate safety...
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The Director of Biostatistics is a hands‑on statistical leader responsible for the design, analysis, and interpretation of Phase 1–Phase 3 clinical trials with a primary focus on inflammation and oncology indications. This role combines scientific leadership with active execution and intensive CRO oversight, ensuring high‑quality statistical deliverables across outsourced clinical studies.
The Director will work closely with Clinical Development and external partners to drive trial design, analysis strategies, and...
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Monte Rosa Therapeutics is seeking an experienced and strategic Director of Regulatory Affairs to lead and support global regulatory efforts across our development programs, with a focus on immunology. The ideal candidate will be responsible for developing and executing regulatory strategies that support global product development and registration. This role requires strong regulatory knowledge, leadership skills, and the ability to work effectively in a cross-functional environment. Global regulatory experience is required, and immunology background is preferred. CMC experience is a plus.