Monte Rosa Therapeutics is seeking a highly motivated and innovative synthetic chemist to contribute to the advancement of our molecular glue degrader (MGD) platform. This role is ideally suited to a scientist with deep expertise in synthetic organic chemistry and a strong track record in developing novel methodologies to access differentiated chemical space.

Working within a highly collaborative and interdisciplinary environment, you will play a key role in designing and expanding proprietary small-molecule libraries to support the discovery of transformative therapies. The position calls for scientific creativity, technical excellence, and the ability to bridge cutting-edge synthetic chemistry with modern medicinal chemistry principles.

• Design and develop innovative small-molecule libraries targeting previously undruggable proteins using MGD approaches
• Act as a key driver in the evolution of the chemistry platform through the development of novel synthetic methodologies and reaction design
• Plan and oversee synthesis strategies executed through a global CRO network
• Integrate biological data (ADME, pharmacology) to inform compound design and optimization
• Collaborate closely with multidisciplinary teams (chemistry, biology, computational sciences) to ensure timely delivery of project milestones
• Strengthen technical capabilities to enhance innovation and efficiency
• Document and communicate scientific findings through internal reports, patents, and peer-reviewed publications

• PhD in Synthetic Organic Chemistry; postdoctoral experience in academia or industry is preferred
• Strong expertise in complex molecule synthesis and/or reaction and methodology development
• Demonstrated track record of scientific impact through publications and/or patents
• Solid understanding of medicinal chemistry principles and their application in drug discovery
• Experience in parallel synthesis would be advantageous
• Experience with CRO collaborations is advantageous but not essential, including exposure to outsourced synthesis strategies
• Sound understanding of preclinical drug discovery, including ADME and developability considerations
• Familiarity with chemical databases, visualization tools, and molecular modelling (e.g. Maestro)
• Awareness of emerging discovery modalities (e.g. DEL, direct-to-biology approaches)
• Excellent interpersonal and communication skills, with the ability to foster effective scientific collaboration
• Proactive, forward-thinking mindset with a strong interest in innovation and continuous development