Monte Rosa Therapeutics (MRT) seeks to recruit an experienced, creative and highly talented DMPK and ADME Scientist who is eager will assit in leading the discovery and development effort to grow the drug pipelines, as well as help lead external GxP compliance research efforts. The Scientist will work MRTx colleagues to participate in all stages of DMPK and ADME assessments, from initial compound screening through to IND and NDA regulatory submissions. Working with Research, Bioanalytical and Clinical Science subject matter experts, provides scientific expertise to ensure that clinical candidates with acceptable drug development characteristics are identified and appropriately characterized. Represents Preclinical Development on Research and Development teams and regularly interfaces with internal and external colleagues to ensure timely and accurate dissemination of DMPK and ADME findings.

· Work closely with the medicinal chemistry team, the Scientist Position will facilitate the Nonclinical Development efforts in troubleshooting and guidance to the discovery project team with a particular focus on optimizing properties for oral administration
· Represent Nonclinical Development to project teams and present our work in the interpretation of ADME experimental data related to the in vitro and in vivo animal PK and biotransformation.
· Continually learn in vitro ADME and in vivo animal PK analysis (Winnolin)
· Coordinate outsourced in vitro and in vivo DMPK studies
· Explore new technologies and capabilities in discovery DMPK space
· Strong written and oral communication to support internal communication of data, study reports and regulatory documentation.
· Ability to work on multiple projects in a matrixed organizational structure
· Aide the Nonclinical Development & Clinical Pharmacology team’s activities across multiple project phases, including lead discovery, lead optimization, and regulatory filings.

· PhD/MS 3+ years of drug discovery industry experience in Drug Metabolism, Pharmacokinetics, Pharmaceutical Chemistry, Toxicology, or a related scientific discipline.
· Effective management of internal and external collaborations/service providers (CROs)
· Build relationships with peers and partners outside of Nonclinical Development & Clinical Pharmacology to enable high team performance.
· Demonstrates novel, innovative solutions to challenging problems using an extremely high degree of scientific discretion, intuition, and integrity.
· Strong collaboration and innovative skills across subject areas representing DMPK as a project team representative within the core team is a key requirement.
· Experience in the design, conduct, and interpretation of in vitro and in vivo ADME and animal PK studies.
· Ability to work on site 100% is required