Monte Rosa Therapeutics seeks to recruit a highly motivated Analytical Chemistry/Compound Management scientist eager to enable the discovery of molecular glue degraders (MGDs). The successful candidate will be a key contributor responsible for the characterization of novel small-molecule glue-based degraders, enabling Monte Rosa’s growing pipeline. The scientist will independently perform compound purity assays, including proactive and retrospective analyses of internal libraries while supporting associated compound management activities.

Compound Management

· Process compound requests with accuracy and efficiency using automated workflows, liquid handling tools, and sample management systems

· Prepare 384-well compound plates for follow-ups for high throughput screens, ensuring quality and timely delivery

· Maintain the integrity of the compound management process by performing quality control procedures on liquid handling equipment and troubleshooting issues

· Maintain accurate records of compound intake, distribution, and storage with LIMS

· Accurately weigh, dissolve, and transfer compound aliquots

· Closely collaborate with team members to accurately and efficiently fulfill compound distribution requests

Analytical Chemistry

· Key operations leader for acquisition, processing, publishing, and interpreting compound purity data (e.g., LCMS QC)

· Accurately and efficiently fulfill compound purity assessment requests from team members

· Maintain detailed internal library purity measurement records

· Regularly prepare and present data summaries to key stakeholders

· Liaise with external vendors to support the organization's analytical chemistry needs

Collaboration and Communication

· Work closely with the high throughput screening scientists to ensure timely delivery of compounds for screening campaigns.

· Collaborate with the Compound Management group in Basel to ensure the uniformity of processes across the organization

· Confer with team members across both sites to maintain in-house LCMS instrumentation and associated peripherals

· BS or MS (or equivalent) in chemistry or related discipline

· 5~8 (BS) or 3~6 (MS) years of experience in an analytical chemistry lab setting, preferably with prior experience in the biotechnology or pharmaceutical industry

· Prior experience in acquiring, processing, and analyzing small molecule LCMS data

· Experience operating liquid handlers (e.g., Hamilton VANTAGE, Echo) and related automation instrumentation

· Excellent communication skills, including the ability to summarize large data sets to enable strategic decision-making

· Keen attention to detail and timely upkeep of accurate experimental records