Monte Rosa Therapeutics is seeking passionate Research Associate, Discovery Technologies to help us to eliminate disease causing proteins through targeted protein degradation­­­–a novel and exciting way of drugging proteins that until recently were considered un-druggable.  The candidates will gain hands-on experience within a particular area of interest in an early-stage drug discovery environment. You will work with an industry leader who will direct and mentor you on your project, as well as expose you to other drug discovery projects and involve you in the process of solving complex biological questions.  You will be joining a diverse, thoughtful, fun and collaborative environment that emphasizes teamwork and putting people first!

• You will employ various technologies to identify targets of molecular glue degraders – a skillset with broad applicability in a range of drug discovery approaches.
• You will implement and compare pooled and arrayed approaches for CRISPR/Cas9 KO screens utilizing techniques such as flow cytometry, luminescence-based assays, western blotting, and sequencing.
• You will establish complex immunoprecipitation assays as an orthogonal approach to CRISPR/Cas9 KO screening.
• You will collaborate with different functions within the company and attend and present your data at team and project meetings.

• • Our preference is for a student currently in a master’s degree program in Cell Biology, Molecular Biology, or a life science field.
  • Proficiency in English (written and spoken).
  • Strong desire to learn the most advanced approaches in drug discovery and targeted protein degradation.
  • Previous experience with mammalian cell culture, molecular biology / biochemical techniques (e.g. Western Blot, DNA extraction, PCR) are required. Prior experience with generation of lentivirus (working under BSL2 standards) and sequencing is desirable.
  • Is a fast learner and enjoys working in a team-based environment.